Student Research Symposium Program Portal: Submission #104

Abstract Cocrystals are of significant interest to the pharmaceutical industry and researchers because they can improve the properties of active pharmaceutical ingredients (API), such as solubility, stability, and bioavailability. In the article "New cocrystals of ezetimibe with L-proline and imidazole" by Shimpi et al., Differential Scanning Calorimetry (DSC) apparatus was used to investigate the thermal properties of this cocrystal. L-Proline is a naturally occurring amino acid that plays a role in protein synthesis and structural stability, while Ezetimibe is a cholesterol-lowering drug that inhibits intestinal cholesterol absorption. The cocrystal of L-Proline and Ezetimibe is being examined for its thermal properties, specifically through the melting point phase diagram. However, the melting point phase diagram was determined from the solids resulting from solutions with varied mole fractions of L-Proline and Ezetimibe to see if the cocrystal would be evident from the data.
Therefore, the purpose of the current research is to determine and present the melting point phase diagram of this cocrystal. This method provides an alternative to DSC and allows for a better understanding of its thermal behavior.