Research Symposium Program - Individual Details

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5th annual Undergraduate Research Symposium, April 17, 2025

Eleni Rodriguez she/her C - 5 R - 3

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BIO

My name is Eleni Rodriguez, and I want to be a psychiatrist. To be a psychiatrist is to be someone who is willing to listen, understand, and organize heavy thoughts and feelings to benefit the person sharing them. I want to be able to do this for as many people as I can, and to do so, having a strong foundation on medications and the way they affect someone is beyond valuable. Research in this field is constantly built upon, and the more we learn, the more we can help others. It is a privilege for someone to place their trust in me, and I must have not only the standard on-paper qualifications, but the ability to apply my knowledge and prove that this trust is warranted. I want to be someone that my future clients can faithfully rely on.

Melting Point Phase Diagram of L-Proline and Diclofenac Cocrystal

Authors: Eleni Rodriguez, Paul Baures
Student Major: Psychology
Mentor: Paul Baures
Mentor's Department: Chemistry
Mentor's College: Florida State University-Panama City
Co-Presenters:

Abstract

Cocrystals are a vital part to pharmaceuticals, as they can be created to improve the properties of substances. The formation of cocrystals can make a drug have stronger efficiency, better bioavailability, or even generate a new form of the same drug that could just make it more easily absorbed. There is a wide range of benefits from their developments. L-Proline and diclofenac’s cocrystal directly improves the low solubility of diclofenac, a commonly used non-steroidal anti-inflammatory drug (NSAID), allowing for greater absorption into the body when taken. Although this cocrystal is known, a melting point phase diagram for it has yet to be determined and analyzed to observe its correlation to preexisting differential scanning calorimetry (DSC) data. Various mole fractions of L-Proline and diclofenac are prepared in methanol and left to crystallize, and then the melting points of these crystals will be taken in order to determine and present the melting point phase diagram. This will allow for a visual representation of the cocrystal’s unique properties and its solid to liquid phase transition.

Keywords: cocrystal, melting point, phase diagram, L-Proline, Diclofenac